Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia - GSE26472 [Pneumonia, Sepsis] (Illumina: Mouse6 V2)
Tracking the molecular patterns of a common response across tissues in murine sepsis to refine treatment strategies - GSE23767 [Sepsis] (Illumina: Mouse6 V2)
Transcriptomic profiles of blood in murine polymicrobial sepsis - GSE36608 [Sepsis] (Illumina: Mouse6 V2)
T cell and Monocyte Specific RNAseq Analysis in Septic and Non Septic Critically-Ill Patients and in Patients with Cancer - GSE133822 [Sepsis, Critically-Ill Non Septic, Metastatic Colon Cancer] (Ensembl: Human Ensembl Gene)
Peripheral blood cells expression data form 7 patients with severe pdm (H1N1) influensa and 7 gender and age matched healthy controls - GSE27131 [Influenza virus H1N1, Influenza (A/H1N1 new subtype), Influenza A virus subtype H1N1, Septic Influenza] (Affymetrix: HG 1.0 ST)
Gene expression patterns in septic and non-septic shock postsurgical patients - GSE131761 [Septic Shock (SS)] (Agilent: Agilent_026652)
Whole blood transcriptional responses of very preterm infants during late-onset sepsis - GSE138712 [Sepsis] (Ensembl: Human Ensembl Gene)
Whole blood RNA sequencing in idiopathic pneumonia syndrome reveals a unique transcriptomic profile compared to ARDS-GSE84439 [Sepsis, Acute respiratory distress syndrome due to sepsis (ARDS), Hematopoietic stem cell transplantation (HSCT)] (Ensembl: Human Ensembl Gene)
Diagnosis of childhood bacterial and viral infection using host RNA expression - Discovery set and Inflammatory validation cohort - GSE72829-GPL10558 - [Bacterial and Viral Infection, Henoch-Schonlein Purpura (HSP), Juvenile Idiopathic Arthritis (JIA)] (Illumina: HT12 V4)
Diagnosis of childhood bacterial and viral infection using host RNA expression - validation set - GSE72829-GPL6947 [Bacterial Infection, Viral Infection] (Illumina: HT12 V3)
Diagnosis of childhood bacterial and viral infection using host RNA expression - Meningococcal validation cohort - GSE72829-GPL6883 - [Sepsis, Meningococcal sepsis (Meningococcal septicemia)] (Illumina: Hu V3 Ref 8)
Skeletal muscle transcriptome in ICU patient suffering from sepsis induced multiple organ failure - GSE13205 [Sepsis induced multiple organ failure (MOF)] (Affymetrix: HG-U133_Plus_2)
A Transcriptome Fingerprinting Assay for Clinical Immune Monitoring (Sepsis Datasets)-GSE100159 [Sepsis, Septicemic Melioidosis] (Illumina: Human V3 WG6)
Hosts responses in critical disease caused by pandemic H1N1 - GSE21802 [Influenza virus H1N1, Influenza (A/H1N1 new subtype), Influenza A virus subtype H1N1, Septic Influenza] (Illumina: Human_6_V2_Beta)
Peripheral blood RNA gene expression profiling in patients with bacterial meningitis - GSE40586 [Bacterial meningitis (Meningitis B or BM)] (Affymetrix: HG 1.0 ST)
Temporal Analysis of Platelets as Cytotoxic Mediators in Sepsis-induced Acute Lung Injury (ALI) - GSE10361 [Acute respiratory distress syndrome due to sepsis (ARDS) or Acute Lung Injury (ALI)] (Affymetrix: HG-U133A)
Acute and convalescence PBMC gene expression in patients with Systemic Capillary Leak Syndrome - GSE97287 [Systemic capillary leak syndrome (Clarkson's Disease) - Rare disease] (Illumina: HT12 V4)
Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma - GSE43397 [Systemic inflammation (SI), Asthma] (Illumina: Human8 V2)
Post-natal age is a critical determinant of the neonatal host response to sepsis - GSE69686 [Sepsis, Clinical Sepsis, Chorio (chorioamnionitis exposure)] (Affymetrix: hGlue_3_0)
An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation - GSE63311 [Sepsis] (Ensembl: Human Ensembl Gene)
Whole blood transcriptome analysis of Septic shock patients according to early therapy response - GSE110487 [Septic Shock (SS)] (Ensembl: Human Ensembl Gene)
Gene expression patterns in blood leukocytes discriminate patients with acute infections - GSE6269 - GPL570 - [Blood infection due to Influenza A virus, Staphylococcus aureus (S. aureus), Streptococcus pneumoniae (S. pneumoniae), Sepsis] (Affymetrix: HG-U133_Plus_2)
Gene expression patterns in blood leukocytes discriminate patients with acute infections - GSE6269 - GPL96 [Influenza A virus, Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Streptococcus pneumoniae (S. pneumoniae), Sepsis] (Affymetrix: HG-U133A)
Enhanced Monocyte Response & Decreased Central Memory T Cells in Children with Invasive Staphylococcus aureus Infections - GSE16129 - GPL6106 [Staphylococcus aureus (S. aureus)] (Illumina: Sentrix Hu-6 v2)
Enhanced Monocyte Response & Decreased Central Memory T Cells in Children with Invasive Staphylococcus aureus Infections - GSE16129 - GPL97 [Staphylococcus aureus (S. aureus)] (Affymetrix: HG-U133B)
Enhanced Monocyte Response & Decreased Central Memory T Cells in Children with Invasive Staphylococcus aureus Infections - GSE16129 - GPL96 [Staphylococcus aureus (S. aureus)] (Affymetrix: HG-U133A)
Gene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans - GSE33341 - GPL571 [Staphylococcus aureus (S. aureus), Escherichia coli (E. coli)] (Affymetrix: HG-U133A)
Gene expression in peripheral mononuclear cells from septic patients secondary to community acquired pneumonia: patterns of gene expression and outcomes - GSE48080 [Sepsis, Septic shock (SS)] (Agilent: Agilent-014850)
Systemic inflammatory response syndrome and septic shock - GSE4607 [Systemic Inflammatory Response Syndrome (SIRS), Septic Shock (SS)] (Affymetrix: HG-U133_Plus_2)
Pediatric septic shock - GSE8121 [Septic Shock (SS)] (Affymetrix: HG-U133_Plus_2)
Validation of Genome-wide Expression patterns in Pediatric Septic Shock - GSE9692 [Septic Shock (SS)] (Affymetrix: HG-U133_Plus_2)
Microarray Analysis of Acute Lung Injury - GSE10474 [Sepsis, Acute respiratory distress syndrome due to sepsis (ARDS) or Acute Lung Injury (ALI)] (Affymetrix: HG-U133A)
Expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum - GSE13904 [Systemic inflammatory response syndrome (SIRS), Sepsis, and Septic Shock (SS)] (Affymetrix: HG-U133_Plus_2)
Gene-expression profiling of peripheral blood mononuclear cells in sepsis - GSE9960 [Sepsis, SIRS] (Affymetrix: HG-U133_Plus_2)
Development and Validation of a Novel Molecular Biomarker Diagnostic Test for the Early Detection of Sepsis - GSE28750 [Sepsis and post-surgical] (Affymetrix: HG-U133_Plus_2)
Inflammasome-regulated cytokines are critical mediators of lung injury in humans - GSE32707 [Systemic inflammatory response syndrome (SIRS), Sepsis, Acute respiratory distress syndrome due to sepsis (ARDS)] (Illumina: HT12 V4)
Blood transcriptome of human bacterial and influenza A pneumonia - GSE40012 [Bacterial pneumonia, Influenza A pneumonia, Systemic Inflammatory Response Syndrome (SIRS)] (Illumina: HT12 V3)
Identification of biomarkers of response to IFNg during endotoxin tolerance: application to septic shock - GSE46914 [Sepsis Shock (SS), Lipopolysaccharide (LPS) exposure] (Affymetrix: HG-U133_Plus_2)
Early and dynamic changes in gene expression in septic shock patients: a genome wide approach - GSE57065 [Septic Shock (SS)] (Affymetrix: HG-U133_Plus_2)
Alarmins MRP8 and MRP14 induce stress-tolerance in phagocytes under sterile inflammatory conditions - GSE61477 [Lipopolysaccharide (LPS) and MRP8-MRP14 exposure] (Illumina: HT12 V4)
CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray - GSE55537 [Escherichia coli (E. coli) exposure] (Affymetrix: HG 1.0 ST)
Biomarker-based classification of bacterial and fungal whole-blood infections in a genome-wide expression study - GSE65088 [Bacterial Infection] (Illumina: HT12 V4)
Unique Patients from the Genomics of Pediatric SIRS and Septic Shock Investigators (GPSSSI) - GSE66099 [Systemic Inflammatory Response Syndrome (SIRS), Sepsis, Septic Shock (SS)] (Affymetrix: HG-U133_Plus_2)
A Blood Transcriptional Diagnostic Assay for Septicemic Melioidosis - GSE69528 [Septicemic Melioidosis, Sepsis, Infection] (Illumina: HT12 V4)
Transcriptomic profiling of the inflammatory response after trauma - GSE70311 [Systemic Inflammatory Response Syndrome (SIRS), Sepsis] (Illumina: HT12 V4)
SRT2014 and the whole blood leukocyte transcriptional response during human endotoxemia - GSE48119 [Lipopolysaccharide (LPS) exposure] (Illumina: HT12 V3)
Defining RNA Transcriptional Biosignatures to Distinguish Febrile Infants 60 Days of Age and Younger with Bacterial vs Non-Bacterial Infections- GSE64456 [Bacterial Infection] (Illumina: HT12 V4)
Widespread downregulation of cardiac mitochondrial and sarcomeric genes in patients with sepsis - GSE79962 [Sepsis, Dilated cardiomyopathy (DCM), Ischemic heart disease (IHD; aka ischemic cardiomyopathy)] (Affymetrix: HG 1.0 ST)
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages - GSE83824 [Lipopolysaccharide (LPS) exposure] (Illumina: HT12 V4)
Transcriptome of the septic shock after treatment by activated protein C (Xigris) - GSE33119 [Septic Shock (SS)] (Affymetrix: HG-U133_Plus_2)
Fractalkine receptor CX3CR1 and leukocyte Ig-like receptor B2 LILRB2 are prognostic biomarkers in septic shock - GSE95233 [Septic Shock (SS)] (Affymetrix: HG-U133_Plus_2)
A network-based analysis of systemic inflammation in humans - GSE3284 [Systemic Inflammation (SI), Intravenous Bacterial Endotoxin, Lipopolysaccharide Exposure (LPS)] (Affymetrix: HG-U133_Plus_2)
In vitro: Whole blood stimulation- GSE30101 (Illumina: HT12 V3)
Whole Blood Transcriptional Modules generated on Illumina Hu-6 V2 Beadchips - GSE29536 [Human Immunodeficiency Virus (HIV), Tuberculosis (TB), Sepsis, Systemic Lupus Erythematosus (SLE), Systemic Arthritis (SoJIA), B-Cell Deficiency, Liver Transplant] (Illumina: Human_6_V2_Beta)
Genome-wide analysis of whole blood transcriptional response to community-acquired Staphylococcus aureus infection in vivo - GSE30119 [Staphylococcus aureus (S. aureus)] (Illumina: HT12 V3)
Whole blood transcriptome of survivors and nonsurvivors of sepsis - GSE54514 [Sepsis] (Illumina: HT12 V3)
Expression of Neutrophil-related genes in patients with early sepsis-induced ARDS - GSE66890 [Sepsis, Acute respiratory distress syndrome due to sepsis (ARDS)] (Affymetrix: HG 1.0 ST)
Genomic Transcriptional Profiling Identifies a Blood Biomarker Signature for the Diagnosis of Septicemic Melioidosis - GSE13015 - GPL6947 [Septicemic Melioidosis, Sepsis, Type 2 Diabetes (T2D)] (Illumina: HT12 V3)
Genomic Transcriptional Profiling Identifies a Blood Biomarker Signature for the Diagnosis of Septicemic Melioidosis - GSE13015 - GPL6106 [Septicemic Melioidosis, Sepsis, Infection, Type 2 diabetes (T2D)] (Illumina: Sentrix Hu-6 v2)
Marked alterations of neutrophil functions during sepsis-induced immunosuppression - GSE64457 [Septic Shock (SS)] (Affymetrix: HG-U133_Plus_2)
Stimulation by LPS and HMGB1 in peripheral blood neutrophils from patients with sepsis-induced acute lung injury - GSE3037 [Sepsis, Lipopolysaccharide (LPS) and HMGB1 exposure] (Affymetrix: HG-U133A)
Whole blood mRNA expression profiling of host molecular networks in neonatal sepsis - GSE25504 - GPL570 - [Sepsis, Infection] (Affymetrix: HG-U133_Plus_2)
Whole blood mRNA expression profiling of host molecular networks in neonatal sepsis - GSE25504 - GPL6947 - [Sepsis, Infection] (Illumina: HT12 V3)
Expression data from validation cohort of children with septic shock - GSE26378 [Septic Shock (SS)] (Affymetrix: HG-U133_Plus_2)
Expression data for derivation of septic shock subgroups - GSE26440 [Septic Shock (SS)] (Affymetrix: HG-U133_Plus_2)
Transcriptome analysis of blood monocytes from sepsis patients - GSE46955 [Sepsis, Lipopolysaccharide (LPS) exposure] (Illumina: Human8 V2)
Gene expression profiling in pediatric meningococcal sepsis reveals dynamic changes in NK-cell and cytotoxic molecules - GSE11755 [Sepsis, Meningococcal sepsis (Meningococcal septicemia)] (Affymetrix: HG-U133_Plus_2)
Next generation sequencing of human immune cell subsets across diseases-GSE60424 [Type 1 diabetes (T1D), Amyotrophic lateral sclerosis (ALS), Sepsis, Multiple sclerosis (MS)] (Ensembl: Human Ensembl Gene)
A Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients Plasma - Neutrophils, experiment III -GSE49757 [Septic Plasma Exposure] (Illumina: HT12 V4)
A Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients Plasma - Neutrophils, experiment II - GSE49756 [Septic Plasma Exposure] (Illumina: HT12 V4)
A Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients Plasma - Neutrophils, experiment I - GSE49755 [Septic Plasma Exposure] (Illumina: HT12 V4)
A Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients Plasma - Peripheral blood mononuclear cells, experiment I - GSE49754 [Septic Plasma Exposure] (Illumina: HT12 V4)
A Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients Plasma - Dendritic cells, experiment I - GSE49753 [Septic Plasma Exposure] (Illumina: HT12 V4)
Comparative analysis of monocytes from healthy donors, patients with metastatic breast cancer, sepsis or tuberculosis - GSE65517 [Breast Cancer, Sepsis, Tuberculosis (TB)] (Illumina: HT12 V4)
Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia - GSE26472 [Pneumonia, Sepsis]
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Gene Symbol: ANGPTL4
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| Description | Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia - GSE26472 |
| Purpose | Transcriptional effects in liver, lung and blood samples from mice after intratracheal challenge with either Streptococcus pneumoniae serotype 19 (lobar-pneumonia) or serotype 2 (sepsis) were monitored after 6 and 24 hours and compared to sham (vehicle control).We gratefully acknowledge the BMBF grant within the “Promoting global research excellence in severe sepsis” (PROGRESS) study (01KI07111). |
| Experimental Design | Three tissues x two serotypes x two time resolved treatment groups x four replicates, three tissues x Sham Control x three replicates. |
| Methods | Gene chips were scanned and pre-processed using BeadStudio (version 3.23). Data analysis was carried out using R statistics software (version 2.92) and BioConductor (version 2.4.1). The arrays were normalized organ-wise using variance stabilising normalisation (Huber et al.). |
| Additional Information | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE26472 |
No information available.
| Background | Biotin | Genes001 | Genes005 | Gp95 | Housekeeping | Noise |
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| -- | -- | -- | -- | -- | -- | -- |
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