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Significant Genes


2.0 Fold Change

Disease

Activated protein C treatment for septic shock (1)
Acute respiratory distress syndrome due to sepsis (2)
Bacterial and Viral infection (1)
Bacterial infection (2)
Bacterial infection, Viral infection, Henoch-Schonlein purpura and Juvenile idiopathic arthritis (1)
Bacterial meningitis (1)
Bacterial pneumonia, Influenza A pneumonia, and Systemic inflammatory response syndrome (1)
Blood infection due to Influenza A virus, Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae (2)
Breast cancer, Sepsis, Tuberculosis (1)
E. coli exposure (1)
HIV, Tuberculosis, Sepsis, Systemic Lupus Erythematosus, Systemic Arthritis, B-Cell Deficiency and Liver Transplant (1)
Influenza virus (H1N1) (1)
Intravenous bacterial endotoxin (1)
Lipopolysaccharide and HMGB1 exposure (1)
Lipopolysaccharide and MRP8-MRP14 exposure (1)
Lipopolysaccharide exposure (4)
Meningococcal Sepsis (1)
Sepsis (8)
Sepsis and Meningococcal Sepsis (1)
Sepsis induced multiple organ failure (1)
Sepsis, Acute respiratory distress syndrome due to sepsis (2)
Sepsis, Dilated cardiomyopathy (DCM), ischemic heart disease (IHD; aka ischemic cardiomyopathy) (1)
Sepsis, Septic shock (1)
Septic Plasma Exposure (5)
Septic Shock (8)
Septicemic Melioidosis (4)
Staphylococcus aureus and Escherichia coli blood Infection (1)
Staphylococcus aureus blood Infection (4)
Systemic capillary leak syndrome (Clarkson's Disease) - Rare disease+ (1)
Systemic inflammation (defined in the dataset-associated publication as high CRP and IL-6 plasma levels) (1)
Systemic inflammatory response syndrome, Sepsis (1)
Systemic inflammatory response syndrome, sepsis, Acute respiratory distress syndrome due to sepsis (1)
Systemic inflammatory response syndrome, sepsis, and septic shock (2)
Systemic inflammatory response syndrome, Septic Shock (1)
Type 1 diabetes, Amyotrophic lateral sclerosis, sepsis, and multiple sclerosis (1)

Sample Source

Cardiac tissue (1)
Dendritic Cells (1)
Induced sputum (1)
Lymphocytes (1)
Macrophages (1)
Monocytes (5)
Neutrophils (5)
PBMC (10)
vastus lateralis (1)
Whole Blood (44)

Species

Homo sapiens (67)

Platform

Affymetrix HG-U133A (6)
Affymetrix HG-U133B (1)
Affymetrix HG-U133_Plus_2 (19)
Affymetrix hGlue_3_0 v1 (1)
Affymetrix HuGene 1.0 ST v1 (4)
Agilent 014850 v1 (1)
Illumina Genome Analyzer (1)
Illumina HiScan (1)
Illumina HiSeq (3)
Illumina Human-6 v2 (2)
Illumina HumanHT-12 v3 (7)
Illumina HumanHT-12 v4 (15)
Illumina HumanRef-8 v2 (2)
Illumina HumanRef-8 v3 (1)
Illumina HumanWG-6 v2 (2)
Illumina HumanWG-6 v3 (1)

Institution

GEO (67)
Sample Set Platform Species Disease Sample Source Sample Count  
Comparative analysis of monocytes from healthy donors, patients with metastatic breast cancer, sepsis or tuberculosis - GSE65517 [Breast Cancer, Sepsis, Tuberculosis (TB)] Homo sapiens Breast cancer, Sepsis, Tu ... Monocytes 13
A Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients Plasma - Dendritic cells, experiment I - GSE49753 [Septic Plasma Exposure] Homo sapiens Septic Plasma Exposure Dendritic Cells 40
A Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients Plasma - Peripheral blood mononuclear cells, experiment I - GSE49754 [Septic Plasma Exposure] Homo sapiens Septic Plasma Exposure PBMC 40
A Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients Plasma - Neutrophils, experiment I - GSE49755 [Septic Plasma Exposure] Homo sapiens Septic Plasma Exposure Neutrophils 40
A Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients Plasma - Neutrophils, experiment II - GSE49756 [Septic Plasma Exposure] Homo sapiens Septic Plasma Exposure Neutrophils 49
A Transcriptomic Reporter Assay Employing Neutrophils to Measure Immunogenic Activity of Septic Patients Plasma - Neutrophils, experiment III -GSE49757 [Septic Plasma Exposure] Homo sapiens Septic Plasma Exposure Neutrophils 56
Next generation sequencing of human immune cell subsets across diseases-GSE60424 [Type 1 diabetes (T1D), Amyotrophic lateral sclerosis (ALS), Sepsis, Multiple sclerosis (MS)] Homo sapiens Type 1 diabetes, Amyotrop ... Whole Blood 134
Gene expression profiling in pediatric meningococcal sepsis reveals dynamic changes in NK-cell and cytotoxic molecules - GSE11755 [Sepsis, Meningococcal sepsis (Meningococcal septicemia)] Homo sapiens Meningococcal Sepsis Whole Blood, Monocytes ... 41
Transcriptome analysis of blood monocytes from sepsis patients - GSE46955 [Sepsis, Lipopolysaccharide (LPS) exposure] Homo sapiens Lipopolysaccharide exposu ... Monocytes 44
Expression data for derivation of septic shock subgroups - GSE26440 [Septic Shock (SS)] Homo sapiens Septic Shock Whole Blood 130
Expression data from validation cohort of children with septic shock - GSE26378 [Septic Shock (SS)] Homo sapiens Septic Shock Whole Blood 103
Whole blood mRNA expression profiling of host molecular networks in neonatal sepsis - GSE25504 - GPL6947 - [Sepsis, Infection] Homo sapiens Sepsis Whole Blood 63
Whole blood mRNA expression profiling of host molecular networks in neonatal sepsis - GSE25504 - GPL570 - [Sepsis, Infection] Homo sapiens Sepsis Whole Blood 5
Stimulation by LPS and HMGB1 in peripheral blood neutrophils from patients with sepsis-induced acute lung injury - GSE3037 [Sepsis, Lipopolysaccharide (LPS) and HMGB1 exposure] Homo sapiens Lipopolysaccharide and HM ... Neutrophils 24
Marked alterations of neutrophil functions during sepsis-induced immunosuppression - GSE64457 [Septic Shock (SS)] Homo sapiens Septic Shock Neutrophils 23
Genomic Transcriptional Profiling Identifies a Blood Biomarker Signature for the Diagnosis of Septicemic Melioidosis - GSE13015 - GPL6106 [Septicemic Melioidosis, Sepsis, Infection, Type 2 diabetes (T2D)] Homo sapiens Septicemic Melioidosis Whole Blood 67
Genomic Transcriptional Profiling Identifies a Blood Biomarker Signature for the Diagnosis of Septicemic Melioidosis - GSE13015 - GPL6947 [Septicemic Melioidosis, Sepsis, Type 2 Diabetes (T2D)] Homo sapiens Septicemic Melioidosis Whole Blood 39
Expression of Neutrophil-related genes in patients with early sepsis-induced ARDS - GSE66890 [Sepsis, Acute respiratory distress syndrome due to sepsis (ARDS)] Homo sapiens Sepsis, Acute respiratory ... Whole Blood 62
Whole blood transcriptome of survivors and nonsurvivors of sepsis - GSE54514 [Sepsis] Homo sapiens Sepsis Whole Blood 163
Genome-wide analysis of whole blood transcriptional response to community-acquired Staphylococcus aureus infection in vivo - GSE30119 [Staphylococcus aureus (S. aureus)] Homo sapiens Staphylococcus aureus blo ... Whole Blood 143
Diagnosis of childhood bacterial and viral infection using host RNA expression - Meningococcal validation cohort - GSE72829-GPL6883 - [Sepsis, Meningococcal sepsis (Meningococcal septicemia)] Homo sapiens Sepsis and Meningococcal ... Whole Blood 45
A Transcriptome Fingerprinting Assay for Clinical Immune Monitoring (Sepsis Datasets)-GSE100159 [Sepsis, Septicemic Melioidosis] Homo sapiens Septicemic Melioidosis Whole Blood 47
Skeletal muscle transcriptome in ICU patient suffering from sepsis induced multiple organ failure - GSE13205 [Sepsis induced multiple organ failure (MOF)] Homo sapiens Sepsis induced multiple o ... vastus lateralis 21
Hosts responses in critical disease caused by pandemic H1N1 - GSE21802 [Influenza virus H1N1, Influenza (A/H1N1 new subtype), Influenza A virus subtype H1N1] Homo sapiens Influenza virus (H1N1) Whole Blood 40
Whole Blood Transcriptional Modules generated on Illumina Hu-6 V2 Beadchips - GSE29536 [Human Immunodeficiency Virus (HIV), Tuberculosis (TB), Sepsis, Systemic Lupus Erythematosus (SLE), Systemic Arthritis (SoJIA), B-Cell Deficiency, Liver Transplant] Homo sapiens HIV, Tuberculosis, Sepsis ... Whole Blood 410
A network-based analysis of systemic inflammation in humans - GSE3284 [Systemic Inflammation (SI), Intravenous Bacterial Endotoxin, Lipopolysaccharide Exposure (LPS)] Homo sapiens Intravenous bacterial end ... Whole Blood 110
Fractalkine receptor CX3CR1 and leukocyte Ig-like receptor B2 LILRB2 are prognostic biomarkers in septic shock - GSE95233 [Septic Shock (SS)] Homo sapiens Septic Shock Whole Blood 124
Transcriptome of the septic shock after treatment by activated protein C (Xigris) - GSE33119 [Septic Shock (SS)] Homo sapiens Activated protein C treat ... Whole Blood 40
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages - GSE83824 [Lipopolysaccharide (LPS) exposure] Homo sapiens Lipopolysaccharide exposu ... Macrophages, Monocytes 6
Widespread downregulation of cardiac mitochondrial and sarcomeric genes in patients with sepsis - GSE79962 [Sepsis, Dilated cardiomyopathy (DCM), Ischemic heart disease (IHD; aka ischemic cardiomyopathy)] Homo sapiens Sepsis, Dilated cardiomyo ... Cardiac tissue 51
Defining RNA Transcriptional Biosignatures to Distinguish Febrile Infants 60 Days of Age and Younger with Bacterial vs Non-Bacterial Infections- GSE64456 [Bacterial Infection] Homo sapiens Bacterial infection Whole Blood 298
SRT2014 and the whole blood leukocyte transcriptional response during human endotoxemia - GSE48119 [Lipopolysaccharide (LPS) exposure] Homo sapiens Lipopolysaccharide exposu ... Whole Blood 72
Transcriptomic profiling of the inflammatory response after trauma - GSE70311 [Systemic Inflammatory Response Syndrome (SIRS), Sepsis] Homo sapiens Systemic inflammatory res ... Whole Blood 90
A Blood Transcriptional Diagnostic Assay for Septicemic Melioidosis - GSE69528 [Septicemic Melioidosis, Sepsis, Infection] Homo sapiens Septicemic Melioidosis Whole Blood 138
Unique Patients from the Genomics of Pediatric SIRS and Septic Shock Investigators (GPSSSI) - GSE66099 [Systemic Inflammatory Response Syndrome (SIRS), Sepsis, Septic Shock (SS)] Homo sapiens Systemic inflammatory res ... Whole Blood 276
Biomarker-based classification of bacterial and fungal whole-blood infections in a genome-wide expression study - GSE65088 [Bacterial Infection] Homo sapiens Bacterial infection Whole Blood 57
CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray - GSE55537 [Escherichia coli (E. coli) exposure] Homo sapiens E. coli exposure Whole Blood 73
Alarmins MRP8 and MRP14 induce stress-tolerance in phagocytes under sterile inflammatory conditions - GSE61477 [Lipopolysaccharide (LPS) and MRP8-MRP14 exposure] Homo sapiens Lipopolysaccharide and MR ... Monocytes 12
Early and dynamic changes in gene expression in septic shock patients: a genome wide approach - GSE57065 [Septic Shock (SS)] Homo sapiens Septic Shock Whole Blood 107
Identification of biomarkers of response to IFNg during endotoxin tolerance: application to septic shock - GSE46914 [Sepsis Shock (SS), Lipopolysaccharide (LPS) exposure] Homo sapiens Lipopolysaccharide exposu ... PBMC 24
Blood transcriptome of human bacterial and influenza A pneumonia - GSE40012 [Bacterial pneumonia, Influenza A pneumonia, Systemic Inflammatory Response Syndrome (SIRS)] Homo sapiens Bacterial pneumonia, Infl ... Whole Blood 190
Inflammasome-regulated cytokines are critical mediators of lung injury in humans - GSE32707 [Systemic inflammatory response syndrome (SIRS), Sepsis, Acute respiratory distress syndrome due to sepsis (ARDS)] Homo sapiens Systemic inflammatory res ... Whole Blood 144
Development and Validation of a Novel Molecular Biomarker Diagnostic Test for the Early Detection of Sepsis - GSE28750 [Sepsis and post-surgical] Homo sapiens Sepsis Whole Blood 41
Gene-expression profiling of peripheral blood mononuclear cells in sepsis - GSE9960 [Sepsis, SIRS] Homo sapiens Sepsis PBMC 70
Expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum - GSE13904 [Systemic inflammatory response syndrome (SIRS), Sepsis, and Septic Shock (SS)] Homo sapiens Systemic inflammatory res ... Whole Blood 227
Microarray Analysis of Acute Lung Injury - GSE10474 [Sepsis, Acute respiratory distress syndrome due to sepsis (ARDS) or Acute Lung Injury (ALI)] Homo sapiens Sepsis, Acute respiratory ... Whole Blood 34
Validation of Genome-wide Expression patterns in Pediatric Septic Shock - GSE9692 [Septic Shock (SS)] Homo sapiens Septic Shock Whole Blood 45
Pediatric septic shock - GSE8121 [Septic Shock (SS)] Homo sapiens Septic Shock Whole Blood 75
Systemic inflammatory response syndrome and septic shock - GSE4607 [Systemic Inflammatory Response Syndrome (SIRS), Septic Shock (SS)] Homo sapiens Systemic inflammatory res ... Whole Blood 123
Gene expression in peripheral mononuclear cells from septic patients secondary to community acquired pneumonia: patterns of gene expression and outcomes - GSE48080 [Sepsis, Septic shock (SS)] Homo sapiens Sepsis, Septic shock PBMC 23
Gene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans - GSE33341 - GPL571 [Staphylococcus aureus (S. aureus), Escherichia coli (E. coli)] Homo sapiens Staphylococcus aureus and ... Whole Blood 94
Enhanced Monocyte Response & Decreased Central Memory T Cells in Children with Invasive Staphylococcus aureus Infections - GSE16129 - GPL96 [Staphylococcus aureus (S. aureus)] Homo sapiens Staphylococcus aureus blo ... PBMC 56
Enhanced Monocyte Response & Decreased Central Memory T Cells in Children with Invasive Staphylococcus aureus Infections - GSE16129 - GPL97 [Staphylococcus aureus (S. aureus)] Homo sapiens Staphylococcus aureus blo ... PBMC 52
Enhanced Monocyte Response & Decreased Central Memory T Cells in Children with Invasive Staphylococcus aureus Infections - GSE16129 - GPL6106 [Staphylococcus aureus (S. aureus)] Homo sapiens Staphylococcus aureus blo ... PBMC 18
Gene expression patterns in blood leukocytes discriminate patients with acute infections - GSE6269 - GPL96 [Influenza A virus, Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Streptococcus pneumoniae (S. pneumoniae), Sepsis] Homo sapiens Blood infection due to In ... PBMC 97
Gene expression patterns in blood leukocytes discriminate patients with acute infections - GSE6269 - GPL570 - [Blood infection due to Influenza A virus, Staphylococcus aureus (S. aureus), Streptococcus pneumoniae (S. pneumoniae), Sepsis] Homo sapiens Blood infection due to In ... PBMC 22
Whole blood transcriptome analysis of Septic shock patients according to early therapy response - GSE110487 [Septic Shock (SS)] Homo sapiens Septic Shock Whole Blood 62
Diagnosis of childhood bacterial and viral infection using host RNA expression - validation set - GSE72829-GPL6947 [Bacterial Infection, Viral Infection] Homo sapiens Bacterial and Viral infec ... Whole Blood 146
An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation - GSE63311 [Sepsis] Homo sapiens Sepsis Whole Blood 83
Peripheral blood RNA gene expression profiling in patients with bacterial meningitis - GSE40586 [Bacterial meningitis (Meningitis B or BM)] Homo sapiens Bacterial meningitis Whole Blood 39
Post-natal age is a critical determinant of the neonatal host response to sepsis - GSE69686 [Sepsis, Clinical Sepsis, Chorio (chorioamnionitis exposure)] Homo sapiens Sepsis Whole Blood 149
Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma - GSE43397 [Systemic inflammation (SI), Asthma] Homo sapiens Systemic inflammation (de ... Induced sputum 50
Acute and convalescence PBMC gene expression in patients with Systemic Capillary Leak Syndrome - GSE97287 [Systemic capillary leak syndrome (Clarkson's Disease) - Rare disease] Homo sapiens Systemic capillary leak s ... PBMC 19
Temporal Analysis of Platelets as Cytotoxic Mediators in Sepsis-induced Acute Lung Injury (ALI) - GSE10361 [Acute respiratory distress syndrome due to sepsis (ARDS) or Acute Lung Injury (ALI)] Homo sapiens Acute respiratory distres ... Whole Blood 9
Diagnosis of childhood bacterial and viral infection using host RNA expression - Discovery set and Inflammatory validation cohort - GSE72829-GPL10558 - [Bacterial and Viral Infection, Henoch-Schonlein Purpura (HSP), Juvenile Idiopathic Arthritis (JIA)] Homo sapiens Bacterial infection, Vira ... Whole Blood 340
Whole blood RNA sequencing in idiopathic pneumonia syndrome reveals a unique transcriptomic profile compared to ARDS-GSE84439 [Sepsis, Acute respiratory distress syndrome due to sepsis (ARDS), Hematopoietic stem cell transplantation (HSCT)] Homo sapiens Acute respiratory distres ... Whole Blood 23
Whole blood transcriptional responses of very preterm infants during late-onset sepsis - GSE138712 [Sepsis] Homo sapiens Sepsis Whole Blood 18
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