Inflammasome-regulated cytokines are critical mediators of lung injury in humans - GSE32707

A microarray analysis involving whole blood samples isolated from critically ill patients in the medical intensive care unit at Brigham and Women's Hospital. Four groups of intubated subjects undergoing mechanical ventilation were recruited for the study: those with sepsis alone (Sepsis), those with sepsis + ARDS (se/ARDS), those with SIRS (SIRS), and those whithout sepsis, SIRS, or ARDS (untreated). Blood was obtained from patients on the day of admission (day 0) and 7 days later. RNA was isolated from the whole blood samples and microarrays were prepared to determine differential gene expression between the four groups.

Total RNA obtained from whole blood samples of critically ill patients

Systemic inflammatory response syndrome (2021 ICD-10-CM code* = R65.1)

Sepsis (2021 ICD-10-CM code* = A41)

Acute respiratory distress syndrome due to sepsis (2021 ICD-10-CM code* = J80-A41)

The data were normalised using quantile normalisation with GenomeStudio

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE32707