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Clinical

Gene expression profiling in pediatric meningococcal sepsis reveals dynamic changes in NK-cell and cytotoxic molecules - GSE11755

Purpose

Meningococcal sepsis remains an important cause of childhood morbidity and mortality. Largely due to logistic complexities of research in young children with acute ...

Hypothesis

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Experimental Design

In this prospective case-control study, six children with meningococcal sepsis were included. Blood was drawn at four time points (t=0, t=8, t=24 and t=72 h after admission ...

Experimental Variables

Meningococcal sepsis (2021 ICD-10-CM code* = A41.9-A39.4)

Controls

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Methods

Micro-array analysis. Background was removed using robust multichip analysis (RMA) and probe intensity levels were quantile normalized. Array groups were compared based on ...

Additional Information

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Microarray
Affymetrix HG-U133_Plus_2
41 Samples Loaded: 41
Human (Homo sapiens)
Whole Blood , Monocytes , Lymphocytes
Meningococcal Sepsis
Sample Set Spreadsheet
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Samples Preview
Sample ID !Sample Title Grouping Time point
GSM297760 002_P1_Lym_T8 Lymphocyte 8 h 8
GSM297761 003_P1_Lym_T24 Lymphocyte 24 h 24
GSM297762 004_P1_Lym_T72 Lymphocyte 72 h 72
GSM297763 005_P1_Mon_T0 Monocyte 0 h 0
GSM297764 006_P1_Mon_T8 Monocyte 8 h 8
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File
sampleset4000035_sampleannotations.csv
Sample Set Spreadsheet
sampleset4000100_sampleannotations_v1.csv
Sample Set Spreadsheet
Quantile Normalized
Raw Signal
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Clinical Datasource
Links

Samples Viewer / Editor

All fields are editable except the "Sample ID" column. To edit a cell, click within the cell. To edit a "date" cell, click on the calendar icon. To cancel an edit, press the ESC key.

Sample ID !Sample Title Grouping Time point
GSM297760
002_P1_Lym_T8
Lymphocyte 8 h
8
GSM297761
003_P1_Lym_T24
Lymphocyte 24 h
24
GSM297762
004_P1_Lym_T72
Lymphocyte 72 h
72
GSM297763
005_P1_Mon_T0
Monocyte 0 h
0
GSM297764
006_P1_Mon_T8
Monocyte 8 h
8
GSM297765
007_P1_Mon_T24
Monocyte 24 h
24
GSM297766
008_P1_Mon_T72
Monocyte 72 h
72
GSM297767
015_P1_Blo_T24
Whole blood 24 h
24
GSM297768
016_P1_Blo_T72
Whole blood 72 h
72
GSM297769
017_P2_Lym_T0
Lymphocyte 0 h
0
GSM297770
019_P2_Lym_T24
Lymphocyte 24 h
24
GSM297771
020_P2_Lym_T72
Lymphocyte 72 h
72
GSM297772
022_P2_Mon_T8
Monocyte 8 h
8
GSM297773
023_P2_Mon_T24
Monocyte 24 h
24
GSM297774
029_P2_Blo_T0
Whole blood 0 h
0
GSM297775
030_P2_Blo_T8
Whole blood 8 h
8
GSM297776
031_P2_Blo_T24
Whole blood 24 h
24
GSM297777
032_P2_Blo_T72
Whole blood 72 h
72
GSM297778
033_P3_Lym_T0
Lymphocyte 0 h
0
GSM297779
034_P3_Lym_T8
Lymphocyte 8 h
8
GSM297780
035_P3_Lym_T24
Lymphocyte 24 h
24
GSM297781
036_P3_Mon_T0
Monocyte 0 h
0
GSM297782
037_P3_Mon_T8
Monocyte 8 h
8
GSM297783
038_P3_Mon_T24
Monocyte 24 h
24
GSM297784
042_P3_Blo_T0
Whole blood 0 h
0
GSM297785
044_P3_Blo_T24
Whole blood 24 h
24
GSM297786
046_P4_Lym_T8
Lymphocyte 8 h
8
GSM297787
047_P4_Lym_T24
Lymphocyte 24 h
24
GSM297788
048_P4_Mon_T0
Monocyte 0 h
0
GSM297789
057_Cb_Lym
Lymphocyte control
Control
GSM297790
058_Cb_Mon
Monocyte control
Control
GSM297791
060_Cb_Blo
Whole blood control
Control
GSM297792
061_Cc_Lym
Lymphocyte control
Control
GSM297793
064_Cc_Blo
Whole blood control
Control
GSM297794
065_Cd_Lym
Lymphocyte control
Control
GSM297795
066_Cd_Mon
Monocyte control
Control
GSM297796
069_Ca_Lym
Lymphocyte control
Control
GSM297797
070_Ca_Mon
Monocyte control
Control
GSM297798
072_Ca_Blo
Whole blood control
Control
GSM297799
092_P6_Lym_T24
Lymphocyte 24 h
24
GSM297800
093_P6_Mon_T0
Monocyte 0 h
0

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