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SIDRA

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Description

Whole blood mRNA expression profiling of host molecular networks in neonatal sepsis. Subset of GSE25504 using platform GPL6947

Purpose

We aimed to identify the gene network and pathway biology associated with neonatal sepsis by determining genome-wide alterations in host RNA in infected infants

Experimental Design

Samples were obtained from control and infected human neonates.

Experimental Variables

Sepsis (2021 ICD-10-CM code* = A41)

Methods

Raw scan data were background subtracted, VST transformed and subsequently robust spline normalised as performed by the lumi package of Bioconductor. Array probe features that had a present count in one or more samples were retained.

Platform Illumina HumanHT-12 v3
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GSE25504 GPL6947 modified.csv

sampleset4000104_sampleannotations.csv

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