Widespread downregulation of cardiac mitochondrial and sarcomeric genes in patients with sepsis - GSE79962 [Sepsis, Dilated cardiomyopathy (DCM), Ischemic heart disease (IHD; aka ischemic cardiomyopathy)]
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| Description | Widespread downregulation of cardiac mitochondrial and sarcomeric genes in patients with sepsis - GSE79962 |
| Purpose | The mechanism(s) for septic cardiomyopathy in humans is not known. To address this, we performed transcriptional profiling of hearts from patients who died from sepsis, in comparison to non-failing human donor hearts that could not be transplanted for technical reasons. |
| Experimental Design | 20 sepsis patients, 11 ischemic heart disease (IHD), 9 nonischemic dilated cardiomyopathy (DCM), 11 non-failing donors.The additional de-identified, clinical data for GSM2109161-66, GSM2109168-79 (total 18 samples) is provided in the 'Clinical_metadata.xls' (as a series supplementary file). |
| Experimental Variables | Sepsis (2021 ICD-10-CM code* = A41) Dilated cardiomyopathy (DCM) (2021 ICD-10-CM code* = I42.0) Ischemic heart disease (IHD; aka ischemic cardiomyopathy) (2021 ICD-10-CM code* = I25.5) |
| Methods | Raw data scans (in the form of .CEL files) were imported into Partek Genomics Suite 6.6 (Partek, St. Louis, MO) using RMA and quantile normalization together with corrections for %GC content and probe sequences, and probesets were summarized using median polish. |
| Additional Information | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE79962 |
| Platform | Affymetrix HuGene 1.0 ST v1 |
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