Sample Set Annotation Tool: Fractalkine receptor CX3CR1 and leukocyte Ig-like receptor B2 LILRB2 are prognostic biomarkers in septic shock

Study Design
Assay
Sample Info
Files
Info
Samples
Group Sets
Analysis

Purpose

Sepsis is a major health concern, with high morbidity and mortality workdwide. In order to identify prognostic biomarkers in septic shock patients, we performed a microarray study exploring the early modulation of gene expression according to day 28 mortality.Several candidate biomarkers including CX3CR1 and LILRB2 were identified as prognostic biomarkers.

Hypothesis

Experimental Design

51 septic shock patients and 22 healthy volunteers were included in this study. Septic shock patients were sampled twice, at admission, and a second time at D2 or D3. Admission samples from septic shock patients were compared to healthy volunteers, and according to day 28 survival status. Modulation of gene expression between the 2 time points was also analyzed according to day 28 survival.

Experimental Variables

Septic shock (2021 ICD-10-CM code* = R65.21)

Controls

Methods

The data were normalized using RMA methods.

Additional Information

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE95233

Expected Samples:

124 Samples Loaded: 124

Species

Human (Homo sapiens)

Sample Source

Whole Blood

Disease

Septic Shock

Treatment Protocol

Growth Protocol

Extraction Protocol

Storage Conditions

Sample Set Spreadsheet

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Samples Preview

Sample ID	!Sample Title	Age	Gender	group	Grouping
GSM2500349	Blood-CS_500_D00	52	F	Healthy Volunteer	Control
GSM2500350	Blood-CS_526_D00	53	F	Healthy Volunteer	Control
GSM2500351	Blood-CS_529_D00	52	F	Healthy Volunteer	Control
GSM2500352	Blood-CS_530_D00	53	F	Healthy Volunteer	Control
GSM2500353	Blood-CS_535_D00	76	F	Healthy Volunteer	Control

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File
sampleset4000160_sampleannotations (1).csv Sample Set Spreadsheet
sampleset4000160_sampleannotations.csv Sample Set Spreadsheet
sampleset4000160_sampleannotations.csv Sample Set Spreadsheet

Samples Viewer / Editor

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Sample ID	!Sample Title	Age	Gender	Group	Grouping	Time point	Survival	All Days Combined	Septic Shock Time Series
GSM2500349	Blood-CS_500_D00	52	F	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500350	Blood-CS_526_D00	53	F	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500351	Blood-CS_529_D00	52	F	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500352	Blood-CS_530_D00	53	F	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500353	Blood-CS_535_D00	76	F	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500354	Blood-CS_553_D00	50	F	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500355	Blood-CS_598_D00	57	F	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500356	Blood-CS_628_D00	61	F	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500357	Blood-CS_742_D00	51	F	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500358	Blood-CS_789_D00	52	F	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500359	Blood-CS_793_D00	67	F	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500360	Blood-PC_511_D00	61	M	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500361	Blood-PC_513_D00	57	M	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500362	Blood-PC_517_D00	60	M	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500363	Blood-PC_523_D00	57	M	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500364	Blood-PC_528_D00	67	M	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500365	Blood-PC_530_D00	56	M	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500366	Blood-PC_532_D00	62	M	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500367	Blood-PC_534_D00	52	M	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500368	Blood-PC_535_D00	57	M	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500369	Blood-PC_537_D00	60	M	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500370	Blood-PC_538_D00	59	M	Healthy Volunteer	Control	NA	NA	Healthy Control	Healthy Control
GSM2500371	Blood-SV_108_D01	80	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500372	Blood-SV_108_D02	80	M	Septic Shock II	Survivor D02	D02	Survivor	Septic Shock	Septic Shock D02
GSM2500373	Blood-SV_115_D01	59	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500374	Blood-SV_115_D03	59	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500375	Blood-SV_119_D01	68	F	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500376	Blood-SV_119_D02	68	F	Septic Shock II	Survivor D02	D02	Survivor	Septic Shock	Septic Shock D02
GSM2500377	Blood-SV_121_D01	36	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500378	Blood-SV_121_D03	36	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500379	Blood-SV_124_D01	66	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500380	Blood-SV_124_D03	66	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500381	Blood-SV_135_D01	72	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500382	Blood-SV_135_D03	72	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500383	Blood-SV_142_D01	60	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500384	Blood-SV_142_D03	60	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500385	Blood-SV_151_D01	81	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500386	Blood-SV_151_D03	81	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500387	Blood-SV_153_D01	78	F	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500388	Blood-SV_153_D03	78	F	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500389	Blood-SV_016_D01	65	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500390	Blood-SV_016_D02	65	M	Septic Shock II	Survivor D02	D02	Survivor	Septic Shock	Septic Shock D02
GSM2500391	Blood-SV_175_D01	37	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500392	Blood-SV_175_D03	37	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500393	Blood-SV_183_D01	66	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500394	Blood-SV_183_D02	66	M	Septic Shock II	Survivor D02	D02	Survivor	Septic Shock	Septic Shock D02
GSM2500395	Blood-SV_019_D01	80	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500396	Blood-SV_019_D02	80	M	Septic Shock II	Survivor D02	D02	Survivor	Septic Shock	Septic Shock D02
GSM2500397	Blood-SV_209_D01	83	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500398	Blood-SV_209_D03	83	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500399	Blood-SV_211_D01	34	F	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500400	Blood-SV_211_D03	34	F	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500401	Blood-SV_213_D01	27	F	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500402	Blood-SV_213_D02	27	F	Septic Shock II	Survivor D02	D02	Survivor	Septic Shock	Septic Shock D02
GSM2500403	Blood-SV_215_D01	55	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500404	Blood-SV_215_D02	55	M	Septic Shock II	Survivor D02	D02	Survivor	Septic Shock	Septic Shock D02
GSM2500405	Blood-SV_021_D01	76	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500406	Blood-SV_021_D03	76	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500407	Blood-SV_248_D01	66	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500408	Blood-SV_248_D02	66	M	Septic Shock II	Survivor D02	D02	Survivor	Septic Shock	Septic Shock D02
GSM2500409	Blood-SV_027_D01	42	F	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500410	Blood-SV_027_D02	42	F	Septic Shock II	Survivor D02	D02	Survivor	Septic Shock	Septic Shock D02
GSM2500411	Blood-SV_032_D01	76	F	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500412	Blood-SV_032_D03	76	F	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500413	Blood-SV_033_D01	75	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500414	Blood-SV_033_D03	75	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500415	Blood-SV_043_D01	54	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500416	Blood-SV_043_D03	54	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500417	Blood-SV_044_D01	69	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500418	Blood-SV_044_D03	69	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500419	Blood-SV_046_D01	65	F	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500420	Blood-SV_046_D03	65	F	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500421	Blood-SV_054_D01	63	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500422	Blood-SV_054_D03	63	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500423	Blood-SV_069_D01	76	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500424	Blood-SV_069_D03	76	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500425	Blood-SV_070_D01	85	F	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500426	Blood-SV_070_D02	85	F	Septic Shock II	Survivor D02	D02	Survivor	Septic Shock	Septic Shock D02
GSM2500427	Blood-SV_072_D01	25	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500428	Blood-SV_072_D03	25	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500429	Blood-SV_074_D01	70	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500430	Blood-SV_074_D02	70	M	Septic Shock II	Survivor D02	D02	Survivor	Septic Shock	Septic Shock D02
GSM2500431	Blood-SV_080_D01	53	F	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500432	Blood-SV_080_D03	53	F	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500433	Blood-SV_086_D01	70	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500434	Blood-SV_086_D02	70	M	Septic Shock II	Survivor D02	D02	Survivor	Septic Shock	Septic Shock D02
GSM2500435	Blood-SV_093_D01	58	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500436	Blood-SV_093_D03	58	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500437	Blood-SV_095_D01	67	M	Septic Shock II	Survivor D01	D01	Survivor	Septic Shock	Septic Shock D01
GSM2500438	Blood-SV_095_D03	67	M	Septic Shock II	Survivor D03	D03	Survivor	Septic Shock	Septic Shock D03
GSM2500439	Blood-NS_102_D01	85	M	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500440	Blood-NS_102_D02	85	M	Septic Shock II	Non Survivor D02	D02	Non Survivor	Septic Shock	Septic Shock D02
GSM2500441	Blood-NS_123_D01	67	F	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500442	Blood-NS_123_D02	67	F	Septic Shock II	Non Survivor D02	D02	Non Survivor	Septic Shock	Septic Shock D02
GSM2500443	Blood-NS_168_D01	47	M	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500444	Blood-NS_168_D02	47	M	Septic Shock II	Non Survivor D02	D02	Non Survivor	Septic Shock	Septic Shock D02
GSM2500445	Blood-NS_179_D01	65	M	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500446	Blood-NS_179_D02	65	M	Septic Shock II	Non Survivor D02	D02	Non Survivor	Septic Shock	Septic Shock D02
GSM2500447	Blood-NS_018_D01	66	H	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500448	Blood-NS_018_D02	66	H	Septic Shock II	Non Survivor D02	D02	Non Survivor	Septic Shock	Septic Shock D02
GSM2500449	Blood-NS_198_D01	47	F	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500450	Blood-NS_198_D03	47	F	Septic Shock II	Non Survivor D03	D03	Non Survivor	Septic Shock	Septic Shock D03
GSM2500451	Blood-NS_201_D01	48	F	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500452	Blood-NS_201_D02	48	F	Septic Shock II	Non Survivor D02	D02	Non Survivor	Septic Shock	Septic Shock D02
GSM2500453	Blood-NS_212_D01	45	F	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500454	Blood-NS_212_D02	45	F	Septic Shock II	Non Survivor D02	D02	Non Survivor	Septic Shock	Septic Shock D02
GSM2500455	Blood-NS_216_D01	59	M	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500456	Blood-NS_216_D03	59	M	Septic Shock II	Non Survivor D03	D03	Non Survivor	Septic Shock	Septic Shock D03
GSM2500457	Blood-NS_035_D01	78	M	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500458	Blood-NS_035_D03	78	M	Septic Shock II	Non Survivor D03	D03	Non Survivor	Septic Shock	Septic Shock D03
GSM2500459	Blood-NS_036_D01	55	F	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500460	Blood-NS_036_D03	55	F	Septic Shock II	Non Survivor D03	D03	Non Survivor	Septic Shock	Septic Shock D03
GSM2500461	Blood-NS_062_D01	70	F	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500462	Blood-NS_062_D03	70	F	Septic Shock II	Non Survivor D03	D03	Non Survivor	Septic Shock	Septic Shock D03
GSM2500463	Blood-NS_067_D01	72	H	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500464	Blood-NS_067_D03	72	H	Septic Shock II	Non Survivor D03	D03	Non Survivor	Septic Shock	Septic Shock D03
GSM2500465	Blood-NS_068_D01	46	M	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500466	Blood-NS_068_D03	46	M	Septic Shock II	Non Survivor D03	D03	Non Survivor	Septic Shock	Septic Shock D03
GSM2500467	Blood-NS_077_D01	78	F	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500468	Blood-NS_077_D02	78	F	Septic Shock II	Non Survivor D02	D02	Non Survivor	Septic Shock	Septic Shock D02
GSM2500469	Blood-NS_078_D01	53	F	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500470	Blood-NS_078_D03	53	F	Septic Shock II	Non Survivor D03	D03	Non Survivor	Septic Shock	Septic Shock D03
GSM2500471	Blood-NS_081_D01	54	F	Septic Shock II	Non Survivor D01	D01	Non Survivor	Septic Shock	Septic Shock D01
GSM2500472	Blood-NS_081_D03	54	F	Septic Shock II	Non Survivor D03	D03	Non Survivor	Septic Shock	Septic Shock D03

Group Sets View in Gene Expression Browser

Name
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All Samples		View
Septic Shock Time Series	Default	View
Survival Time Series		View
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Module Analysis

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All Days Combined
All Samples
Septic Shock Time Series
Survival Time Series

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