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SRT2014 and the whole blood leukocyte transcriptional response during human endotoxemia - GSE48119 [Lipopolysaccharide (LPS) exposure]

In Progress
Clinical

SRT2014 and the whole blood leukocyte transcriptional response during human endotoxemia - GSE48119

Purpose

Healthy subjects injected with 4ng/kg e.coli LPS treated with placebo or SRT2014

Hypothesis

--

Experimental Design

Double-blind clinical trial

Experimental Variables

Lipopolysaccharide exposure (2021 ICD-10-CM code* = Not Applicable)

Controls

--

Methods

Beadarray, neqc normalization

Additional Information

1. SRT2104 is a selective activator of SIRT1: https://www.genecards.org/cgi-bin/carddisp.pl?gene=SIRT1.

2. ClinicalTrials.gov Identifier: NCT01154101.

3. Randomized Placebo-Controlled Study of SRT2104: https://doi.org/10.1371/journal.pone.0142081.

4. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48119

Microarray
Illumina HumanHT-12 v3
72 Samples Loaded: 72
Human (Homo sapiens)
Whole Blood
Lipopolysaccharide exposure
PAXgene blood tubes
Qiacube paxgene mRNA
Sample Set Spreadsheet
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Samples Preview
Sample ID !Sample Title tissue treatment Grouping Sex
GSM1168911 PLACEBO + SRT2104 2.0g/d [5368138010_A] whole blood PLACEBO + SRT2104 2.0g/d Pre LPS Placebo SRT male
GSM1168912 SRT2104 2.0g/day [5368138010_B] whole blood SRT2104 2.0g/day Pre LPS SRT male
GSM1168913 PLACEBO + SRT2104 2.0g/d [5368138010_C] whole blood PLACEBO + SRT2104 2.0g/d Pre LPS Placebo SRT male
GSM1168914 PLACEBO [5368138010_D] whole blood PLACEBO Pre LPS Placebo male
GSM1168915 PLACEBO [5368138010_E] whole blood PLACEBO Pre LPS Placebo male

Upload Files

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Browse Files

File
sampleset4000167_sampleannotations.csv
Sample Set Spreadsheet
sampleset4000167_sampleannotations.csv
Sample Set Spreadsheet
Log2 Transformed
Raw Signal
  •   |  View in GXB »
Clinical Datasource
Links
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48119
https://www.ncbi.nlm.nih.gov/pubmed/26950237

Samples Viewer / Editor

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Sample ID !Sample Title Tissue Treatment Grouping Sex Status
GSM1168911
PLACEBO + SRT2104 2.0g/d [5368138010_A]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168912
SRT2104 2.0g/day [5368138010_B]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168913
PLACEBO + SRT2104 2.0g/d [5368138010_C]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168914
PLACEBO [5368138010_D]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168915
PLACEBO [5368138010_E]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168916
SRT2104 2.0g/day [5368138010_F]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168917
PLACEBO [5368138010_G]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168918
PLACEBO + SRT2104 2.0g/d [5368138010_H]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168919
SRT2104 2.0g/day [5368138010_I]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168920
PLACEBO + SRT2104 2.0g/d [5368138010_J]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168921
SRT2104 2.0g/day [5368138010_K]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168922
PLACEBO [5368138010_L]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168923
SRT2104 2.0g/day [5368138001_A]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168924
PLACEBO [5368138001_B]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168925
PLACEBO + SRT2104 2.0g/d [5368138001_C]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168926
PLACEBO + SRT2104 2.0g/d [5368138001_D]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168927
SRT2104 2.0g/day [5368138001_E]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168928
PLACEBO [5368138001_F]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168929
SRT2104 2.0g/day [5368138001_G]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168930
PLACEBO [5368138001_H]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168931
PLACEBO + SRT2104 2.0g/d [5368138001_I]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168932
SRT2104 2.0g/day [5368138001_J]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168933
PLACEBO [5368138001_K]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168934
PLACEBO + SRT2104 2.0g/d [5368138001_L]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168935
PLACEBO + SRT2104 2.0g/d [5368138002_A]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168936
SRT2104 2.0g/day [5368138002_B]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168937
PLACEBO + SRT2104 2.0g/d [5368138002_C]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168938
PLACEBO [5368138002_D]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168939
PLACEBO [5368138002_E]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168940
SRT2104 2.0g/day [5368138002_F]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168941
PLACEBO [5368138002_G]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168942
PLACEBO + SRT2104 2.0g/d [5368138002_H]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168943
SRT2104 2.0g/day [5368138002_I]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168944
PLACEBO + SRT2104 2.0g/d [5368138002_J]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168945
SRT2104 2.0g/day [5368138002_K]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168946
PLACEBO [5368138002_L]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168947
SRT2104 2.0g/day [5368138005_A]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168948
PLACEBO [5368138005_B]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168949
PLACEBO + SRT2104 2.0g/d [5368138005_C]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168950
PLACEBO + SRT2104 2.0g/d [5368138005_D]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168951
SRT2104 2.0g/day [5368138005_E]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168952
PLACEBO [5368138005_F]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168953
SRT2104 2.0g/day [5368138005_G]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168954
PLACEBO [5368138005_H]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168955
PLACEBO + SRT2104 2.0g/d [5368138005_I]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168956
SRT2104 2.0g/day [5368138005_J]
whole blood
SRT2104 2.0g/day
Pre LPS SRT
male
Pre SRT
GSM1168957
PLACEBO [5368138005_K]
whole blood
PLACEBO
Pre LPS Placebo
male
Pre SRT
GSM1168958
PLACEBO + SRT2104 2.0g/d [5368138005_L]
whole blood
PLACEBO + SRT2104 2.0g/d
Pre LPS Placebo SRT
male
Pre SRT
GSM1168959
PLACEBO + SRT2104 2.0g/d [5368138011_A]
whole blood
PLACEBO + SRT2104 2.0g/d
Post LPS Placebo SRT
male
Post LPS
GSM1168960
SRT2104 2.0g/day [5368138011_B]
whole blood
SRT2104 2.0g/day
Post LPS SRT
male
Post LPS
GSM1168961
PLACEBO + SRT2104 2.0g/d [5368138011_C]
whole blood
PLACEBO + SRT2104 2.0g/d
Post LPS Placebo SRT
male
Post LPS
GSM1168962
PLACEBO [5368138011_D]
whole blood
PLACEBO
Post LPS Placebo
male
Post LPS
GSM1168963
PLACEBO [5368138011_E]
whole blood
PLACEBO
Post LPS Placebo
male
Post LPS
GSM1168964
SRT2104 2.0g/day [5368138011_F]
whole blood
SRT2104 2.0g/day
Post LPS SRT
male
Post LPS
GSM1168965
PLACEBO [5368138011_G]
whole blood
PLACEBO
Post LPS Placebo
male
Post LPS
GSM1168966
PLACEBO + SRT2104 2.0g/d [5368138011_H]
whole blood
PLACEBO + SRT2104 2.0g/d
Post LPS Placebo SRT
male
Post LPS
GSM1168967
SRT2104 2.0g/day [5368138011_I]
whole blood
SRT2104 2.0g/day
Post LPS SRT
male
Post LPS
GSM1168968
PLACEBO + SRT2104 2.0g/d [5368138011_J]
whole blood
PLACEBO + SRT2104 2.0g/d
Post LPS Placebo SRT
male
Post LPS
GSM1168969
SRT2104 2.0g/day [5368138011_K]
whole blood
SRT2104 2.0g/day
Post LPS SRT
male
Post LPS
GSM1168970
PLACEBO [5368138011_L]
whole blood
PLACEBO
Post LPS Placebo
male
Post LPS
GSM1168971
SRT2104 2.0g/day [5368138003_A]
whole blood
SRT2104 2.0g/day
Post LPS SRT
male
Post LPS
GSM1168972
PLACEBO [5368138003_B]
whole blood
PLACEBO
Post LPS Placebo
male
Post LPS
GSM1168973
PLACEBO + SRT2104 2.0g/d [5368138003_C]
whole blood
PLACEBO + SRT2104 2.0g/d
Post LPS Placebo SRT
male
Post LPS
GSM1168974
PLACEBO + SRT2104 2.0g/d [5368138003_D]
whole blood
PLACEBO + SRT2104 2.0g/d
Post LPS Placebo SRT
male
Post LPS
GSM1168975
SRT2104 2.0g/day [5368138003_E]
whole blood
SRT2104 2.0g/day
Post LPS SRT
male
Post LPS
GSM1168976
PLACEBO [5368138003_F]
whole blood
PLACEBO
Post LPS Placebo
male
Post LPS
GSM1168977
SRT2104 2.0g/day [5368138003_G]
whole blood
SRT2104 2.0g/day
Post LPS SRT
male
Post LPS
GSM1168978
PLACEBO [5368138003_H]
whole blood
PLACEBO
Post LPS Placebo
male
Post LPS
GSM1168979
PLACEBO + SRT2104 2.0g/d [5368138003_I]
whole blood
PLACEBO + SRT2104 2.0g/d
Post LPS Placebo SRT
male
Post LPS
GSM1168980
SRT2104 2.0g/day [5368138003_J]
whole blood
SRT2104 2.0g/day
Post LPS SRT
male
Post LPS
GSM1168981
PLACEBO [5368138003_K]
whole blood
PLACEBO
Post LPS Placebo
male
Post LPS
GSM1168982
PLACEBO + SRT2104 2.0g/d [5368138003_L]
whole blood
PLACEBO + SRT2104 2.0g/d
Post LPS Placebo SRT
male
Post LPS

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