Expression of Neutrophil-related genes in patients with early sepsis-induced ARDS - GSE66890
Clinical study of critically ill patients with sepsis and sepsis-related ARDS with whole blood RNA collected within the first 24 hours of admissionGoal of the study was to determine whether biologically relevant genes were identified to be differentially expressed genes in patients with sepsis alone and sepsis with ARDS
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Prospective observational study, case cohort design
Sepsis (2021 ICD-10-CM code* = A41)
Acute respiratory distress syndrome due to sepsis (2021 ICD-10-CM code* = J80-A41)
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CEL files were generated using AGCC 4.0.0.1567G. The values in the CEL files were then normalized with the RMA normalization method, using the Affymetrix Power Tools suite, version 1.12.0.
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| Sample ID | Gender | !Sample_title | disease state | batch_2 | berlin_ards |
|---|---|---|---|---|---|
| GSM1633778 | male | 301.sepsis_alone | sepsis alone | 0 | 0 |
| GSM1633779 | female | 308.excluded | not meeting the Berlin definition of sepsis with ARDS and that they were excluded from analysis | 0 | 0 |
| GSM1633780 | female | 320.sepsis_with_ARDS | sepsis with ARDS | 0 | 1 |
| GSM1633781 | female | 324.sepsis_with_ARDS | sepsis with ARDS | 0 | 1 |
| GSM1633782 | male | 325.sepsis_alone | sepsis alone | 0 | 0 |
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| Sample ID | Gender | !Sample Title | Disease state | Batch 2 | Berlin Ards | Direct Lung | Age Years | Aecc Ali | Wbc Cells Per Ul | Shock |
|---|---|---|---|---|---|---|---|---|---|---|
| GSM1633778 | male |
301.sepsis_alone |
sepsis alone |
0 |
0 |
1 |
66 |
0 |
7.9 |
1 |
| GSM1633779 | female |
308.excluded |
not meeting the Berlin definition of sepsis with ARDS and that they were excluded from analysis |
0 |
0 |
1 |
39 |
1 |
7.7 |
1 |
| GSM1633780 | female |
320.sepsis_with_ARDS |
sepsis with ARDS |
0 |
1 |
1 |
41 |
1 |
1.2 |
1 |
| GSM1633781 | female |
324.sepsis_with_ARDS |
sepsis with ARDS |
0 |
1 |
1 |
44 |
1 |
11.1 |
1 |
| GSM1633782 | male |
325.sepsis_alone |
sepsis alone |
0 |
0 |
0 |
88 |
0 |
20.3 |
1 |
| GSM1633783 | female |
333.sepsis_alone |
sepsis alone |
0 |
0 |
1 |
86 |
0 |
20.2 |
0 |
| GSM1633784 | male |
337.sepsis_with_ARDS |
sepsis with ARDS |
0 |
1 |
1 |
63 |
1 |
13.9 |
1 |
| GSM1633785 | male |
348.sepsis_alone |
sepsis alone |
0 |
0 |
0 |
47 |
0 |
2.2 |
1 |
| GSM1633786 | male |
350.sepsis_alone |
sepsis alone |
0 |
0 |
1 |
88 |
0 |
13.1 |
0 |
| GSM1633787 | male |
356.sepsis_with_ARDS |
sepsis with ARDS |
0 |
1 |
1 |
49 |
1 |
6.6 |
0 |
| GSM1633788 | male |
357.sepsis_alone |
sepsis alone |
0 |
0 |
1 |
77 |
0 |
12.7 |
1 |
| GSM1633789 | male |
369.sepsis_with_ARDS |
sepsis with ARDS |
0 |
1 |
1 |
59 |
1 |
15.1 |
1 |
| GSM1633790 | male |
387.sepsis_alone |
sepsis alone |
0 |
0 |
0 |
84 |
0 |
18 |
1 |
| GSM1633791 | male |
388.sepsis_with_ARDS |
sepsis with ARDS |
0 |
1 |
0 |
19 |
1 |
12.3 |
1 |
| GSM1633792 | male |
391.excluded |
not meeting the Berlin definition of sepsis with ARDS and that they were excluded from analysis |
0 |
0 |
1 |
53 |
1 |
10 |
0 |
| GSM1633793 | male |
400.sepsis_with_ARDS |
sepsis with ARDS |
0 |
1 |
1 |
25 |
1 |
28.1 |
1 |
| GSM1633794 | female |
403.sepsis_with_ARDS |
sepsis with ARDS |
0 |
1 |
0 |
62 |
1 |
11.1 |
1 |
| GSM1633795 | female |
405.sepsis_alone |
sepsis alone |
0 |
0 |
1 |
80 |
0 |
8.9 |
0 |
| GSM1633796 | other |
407.sepsis_with_ARDS |
sepsis with ARDS |
0 |
1 |
1 |
47 |
1 |
13.1 |
0 |
| GSM1633797 | female |
408.sepsis_alone |
sepsis alone |
0 |
0 |
0 |
52 |
0 |
17.9 |
0 |
| GSM1633798 | female |
409.sepsis_alone |
sepsis alone |
0 |
0 |
0 |
91 |
0 |
4.3 |
1 |
| GSM1633799 | male |
410.sepsis_with_ARDS |
sepsis with ARDS |
0 |
1 |
0 |
66 |
1 |
3.1 |
1 |
| GSM1633800 | female |
412.sepsis_alone |
sepsis alone |
0 |
0 |
0 |
78 |
0 |
7.9 |
0 |
| GSM1633801 | male |
428.sepsis_alone |
sepsis alone |
1 |
0 |
0 |
78 |
0 |
12.7 |
0 |
| GSM1633802 | male |
431.sepsis_alone |
sepsis alone |
1 |
0 |
0 |
62 |
0 |
11.2 |
0 |
| GSM1633803 | male |
446.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
1 |
63 |
1 |
5.4 |
1 |
| GSM1633804 | male |
455.sepsis_alone |
sepsis alone |
1 |
0 |
0 |
84 |
0 |
34.2 |
0 |
| GSM1633805 | male |
460.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
0 |
71 |
1 |
8.8 |
1 |
| GSM1633806 | female |
470.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
1 |
42 |
1 |
6.6 |
1 |
| GSM1633807 | male |
474.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
0 |
85 |
1 |
7.8 |
1 |
| GSM1633808 | male |
476.excluded |
not meeting the Berlin definition of sepsis with ARDS and that they were excluded from analysis |
1 |
0 |
1 |
50 |
1 |
37.4 |
0 |
| GSM1633809 | male |
486.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
1 |
80 |
1 |
17.7 |
1 |
| GSM1633810 | male |
491.sepsis_alone |
sepsis alone |
1 |
0 |
0 |
83 |
0 |
12.4 |
0 |
| GSM1633811 | female |
495.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
1 |
50 |
1 |
11.4 |
0 |
| GSM1633812 | male |
509.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
1 |
77 |
1 |
17.3 |
1 |
| GSM1633813 | female |
523.sepsis_alone |
sepsis alone |
1 |
0 |
0 |
26 |
0 |
19.1 |
0 |
| GSM1633814 | female |
524.sepsis_alone |
sepsis alone |
1 |
0 |
1 |
74 |
0 |
11.1 |
0 |
| GSM1633815 | male |
547.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
0 |
30 |
1 |
32.7 |
1 |
| GSM1633816 | male |
550.sepsis_alone |
sepsis alone |
1 |
0 |
1 |
27 |
0 |
17.7 |
0 |
| GSM1633817 | male |
558.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
1 |
74 |
1 |
1.1 |
0 |
| GSM1633818 | female |
561.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
1 |
69 |
1 |
8.3 |
0 |
| GSM1633819 | female |
563.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
1 |
54 |
1 |
5.6 |
0 |
| GSM1633820 | male |
569.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
1 |
26 |
1 |
11 |
0 |
| GSM1633821 | male |
571.sepsis_alone |
sepsis alone |
1 |
0 |
1 |
67 |
0 |
19.6 |
1 |
| GSM1633822 | female |
582.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
1 |
60 |
1 |
7.3 |
0 |
| GSM1633823 | female |
597.sepsis_alone |
sepsis alone |
1 |
0 |
0 |
19 |
0 |
5.1 |
0 |
| GSM1633824 | female |
605.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
0 |
51 |
1 |
5.9 |
1 |
| GSM1633825 | male |
617.sepsis_alone |
sepsis alone |
1 |
0 |
1 |
56 |
0 |
24.7 |
0 |
| GSM1633826 | female |
618.sepsis_alone |
sepsis alone |
1 |
0 |
0 |
57 |
0 |
15.8 |
1 |
| GSM1633827 | female |
623.excluded |
not meeting the Berlin definition of sepsis with ARDS and that they were excluded from analysis |
1 |
0 |
0 |
81 |
1 |
13.5 |
0 |
| GSM1633828 | male |
631.sepsis_alone |
sepsis alone |
1 |
0 |
1 |
64 |
0 |
15.8 |
1 |
| GSM1633829 | female |
632.sepsis_alone |
sepsis alone |
1 |
0 |
1 |
85 |
0 |
15.8 |
1 |
| GSM1633830 | male |
641.sepsis_alone |
sepsis alone |
1 |
0 |
1 |
67 |
0 |
15.2 |
0 |
| GSM1633831 | male |
649.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
1 |
67 |
1 |
11.5 |
1 |
| GSM1633832 | female |
654.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
0 |
77 |
1 |
3.2 |
1 |
| GSM1633833 | male |
661.sepsis_alone |
sepsis alone |
1 |
0 |
0 |
82 |
0 |
26.3 |
0 |
| GSM1633834 | male |
669.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
1 |
86 |
1 |
11.8 |
1 |
| GSM1633835 | female |
677.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
1 |
71 |
1 |
12.6 |
1 |
| GSM1633836 | female |
682.sepsis_with_ARDS |
sepsis with ARDS |
1 |
1 |
1 |
92 |
1 |
12.1 |
1 |
| GSM1633837 | male |
684.excluded |
not meeting the Berlin definition of sepsis with ARDS and that they were excluded from analysis |
1 |
0 |
1 |
95 |
1 |
13.8 |
0 |
| GSM1633838 | female |
686.sepsis_alone |
sepsis alone |
1 |
0 |
0 |
37 |
0 |
13 |
1 |
| GSM1633839 | female |
690.sepsis_alone |
sepsis alone |
1 |
0 |
1 |
71 |
0 |
11.5 |
1 |
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