Whole blood mRNA expression profiling of host molecular networks in neonatal sepsis. Subset of GSE25504 using platform GPL570
We aimed to identify the gene network and pathway biology associated with neonatal sepsis by determining genome-wide alterations in host RNA in infected infants
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Samples were obtained from control and infected human neonates.
Sepsis (2021 ICD-10-CM code* = A41)
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| Sample ID | !Sample Title | Gender | tissue | Grouping | Birthweight (g) |
|---|---|---|---|---|---|
| GSM1404208 | Con006 | Male | peripheral blood | Control | 4240 |
| GSM1404209 | Con014 | Female | peripheral blood | Control | 2970 |
| GSM1404210 | Con030 | Male | peripheral blood | Control | 3270 |
| GSM1404211 | Inf012 | Female | peripheral blood | Infected | 2150 |
| GSM1404212 | Inf032 | Female | peripheral blood | Infected | 3180 |
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| Sample ID | !Sample Title | Gender | Tissue | Grouping | Birthweight (g) | Bloodculture result | Corrected gestational age (weeks+days) | On antibiotics at time of sample | Other positive results |
|---|---|---|---|---|---|---|---|---|---|
| GSM1404208 | Con006 |
Male |
peripheral blood |
Control |
4240 |
negative |
41+3 |
No |
no |
| GSM1404209 | Con014 |
Female |
peripheral blood |
Control |
2970 |
na |
38+3 |
No |
no |
| GSM1404210 | Con030 |
Male |
peripheral blood |
Control |
3270 |
na |
40+1 |
No |
umbilical swab grew proteus (may represent colonisation) |
| GSM1404211 | Inf012 |
Female |
peripheral blood |
Infected |
2150 |
negative |
34+6 |
No |
CSF: enterovirus on PCR. CSF also grew coag neg staph, CSF WCC 300, RBC 9 |
| GSM1404212 | Inf032 |
Female |
peripheral blood |
Infected |
3180 |
negative |
41+1 |
No |
yes CSF grew Listeria monocytogenes, CSF white cell count 551, RBC 119, urine no growth |
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